The show that stands out from the crowd is The Venture Bros. This show has become must watch TV for me. At first glance it looks like an updated version of Johnny Quest, but it doesn't take long to realize that the similarities are only superficial. The Venture Bros takes full advantage of the Adult in Adult Swim. It's got all the things that you might expect, like robots, villains, and super-science but it also gives you sex, violence, dysfunctional families and a sprinkling of dick jokes.
The Venture family is the focus of the show but the cast of characters that surrounds them is what really makes the show great. Their friends and enemies steal then show every week. Their arch enemy The Monarch has become just as important to the story line of the show as the Ventures. This show is addictive, and you get hooked fast, so check it out. Plus, if I make a Dr. Girlfriend reference you can be in on the joke.
The first 2 seasons are out on DVD but you can still watch episodes every Sunday on Adult Swim. You can also see some episodes at adultswim.com. Do yourself a favor and become a part of team Venture.